Silane molecules with pre-activated and protein-resistant functionalities and silane films comprising such molecules

摘要

The present invention provides a silane molecule which combines preactivated and protein-resistant functionalities in one molecule, the molecule has a general formula: A-(CH2)n-(OÄCH2Üt)m-(CH2)v-Y wherein A is a functional group for binding to a substrate and Y is a functional group for binding to biomolecules. The invention furthermore provides a method for the synthesis of such a silane molecule and a method for depositing a monolayer of such silane molecules onto a substrate. Such a monolayer of silane molecules may be used in biosensors, DNA/protein micro-arrays or other sensor applications. For further lowering the protein binding to the surface of the biosensor, the monolayer may furthermore comprise second silane molecules with formula: B-(CH2)o-(OCH2CH2)r-Z