发明名称 |
COMBINATORIAL MARKING OF CELLS AND CELL STRUCTURES WITH RECONSTITUTED FLUORESCENT PROTEINS |
摘要 |
The present invention relates to the use of split fluorescent proteins to determine whether promoters are coordinately active, whereby the transcriptional expression of incomplete portions of a fluorescent protein is controlled by different promoters and coordinate (not necessarily contemporaneous) promoter activity results in the reconstitution of a fluorescent protein. The present invention, in non-limiting embodiments, may be used to selectively label cells and cell structures in vivo and to demonstrate changes in promoter activity (for example, in developmental biology and drug discovery applications). |
申请公布号 |
WO2005118790(A2) |
申请公布日期 |
2005.12.15 |
申请号 |
WO2005US19717 |
申请日期 |
2005.06.02 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFNEW YORK;CHALFIE, MARTIN;MA, CHARLES;ZHANG, SHIFANG |
发明人 |
CHALFIE, MARTIN;MA, CHARLES;ZHANG, SHIFANG |
分类号 |
A01K67/033;C07K14/435;C12N5/08;C12N15/85 |
主分类号 |
A01K67/033 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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