发明名称 |
METHODS FOR PREDICTION OF CLINICAL OUTCOME TO EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS BY CANCER PATIENTS |
摘要 |
The present invention relates to a method to obtain an expression score to evaluate gene expression in a tissue specimen obtained from a person having or suspected of having cancer comprising:
a) determining by immunohistochemistry a fraction score, wherein the fraction score corresponds to the percentage of cells in the tissue specimen that stain positive for a biomarker;
b) determining an intensity score that corresponds to the staining intensity of the biomarker in the sample of tumor cells;
c) calculating an expression score that is a numerical evaluation of the product of the fraction score and the intensity score. |
申请公布号 |
CA2567293(A1) |
申请公布日期 |
2005.12.15 |
申请号 |
CA20052567293 |
申请日期 |
2005.05.26 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO |
发明人 |
CAPPUZZO, FEDERICO;BUNN, PAUL A., JR.;GARCIA, MARILEILA VARELLA;HIRSCH, FRED R.;FRANKLIN, WILBUR A. |
分类号 |
C12Q1/68;C12N15/18;C12N15/54;C12P19/34;C12Q1/48;G01N33/566;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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