PROCESS FOR INCREASING RSV SURFACE GLYCOPROTEIN YIELDS USING A MUTANT STRAIN OF RSV
摘要
<p>A process for producing isolated and purified respiratory syncytial virus (RSV) fusion (F) and attachment (G) glycoproteins in eukaryotic cell cultures infected with RSV cold-passaged, temperature-sensitive mutant subgroup A2 strain cpts-248/404 results in at least a 5-fold increase in F and G protein yields when compared with the parent A2 strain. Immunogenic compositions comprising the F and/or G protein(s) produced by this process can be formulated for in vivo administration to a host to confer protection against disease caused by RSV.</p>
申请公布号
EP1603940(A2)
申请公布日期
2005.12.14
申请号
EP20040757514
申请日期
2004.03.17
申请人
WYETH HOLDINGS CORPORATION
发明人
ALONSO-CAPLEN, FIRELLI;CUTLER, MARK, WILLIAM;FINO, MIRELI;PURSELL, EARL, JOSEPH;REPETTO, ROBERT, ANTHONY