| 摘要 |
The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-beta-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-beta-hydroxysteroid dehydrogenase type 1 enzyme. |
| 申请人 |
AMGEN INC.;BIOVITRUM AB;HENRIKSSON, MARTIN;HOMAN, EVERT;JOHANSSON, LARS;VALLGARDA, JERK;WILLIAMS, MEREDITH;BERCOT, ERIC;FOTSCH, CHRISTOPHER, H.;LI, AIWEN;CAI, GUOLIN;HUNGATE, RANDALL, W.;YUAN, CHESTER, CHENGUANG;TEGLEY, CHIRSTOPHER;ST. JEAN, DAVID;HAN, NIANHE;HUANG, QI;LIU, QINGYIAN;BARTBERGER, MICHAEL, D.;MONIZ, GEORGE, A.;FRIZZLE, MATTHEW, J. |
发明人 |
HENRIKSSON, MARTIN;HOMAN, EVERT;JOHANSSON, LARS;VALLGARDA, JERK;WILLIAMS, MEREDITH;BERCOT, ERIC;FOTSCH, CHRISTOPHER, H.;LI, AIWEN;CAI, GUOLIN;HUNGATE, RANDALL, W.;YUAN, CHESTER, CHENGUANG;TEGLEY, CHIRSTOPHER;ST. JEAN, DAVID;HAN, NIANHE;HUANG, QI;LIU, QINGYIAN;BARTBERGER, MICHAEL, D.;MONIZ, GEORGE, A.;FRIZZLE, MATTHEW, J. |
