COMPOSITIONS FOR USE IN THE TREATMENT OF MUTANT RECEPTOR TYROSINE KINASE DRIVEN CELLULAR PROLIFERATIVE DISEASES

摘要

Uses of a CDK4 inhibitor in the manufacture of a medicament for treating a subject suffering from a cellular proliferative disease characterized by the presence of a mutant receptor tyrosine kinase are provided. The CDK4 inhibitor is for administration either alone or in combination with at least one of an inhibitor of the mutant receptor tyrosine kinase and an MEK inhibitor. Also provided are compositions, including pharmaceutical formulations and kits thereof, comprising the above inhibitors.