| 发明名称 |
PROHORMON-KONVERTASE EXPRIMIERENDE POLYPEPTID-SYNTHESE |
| 摘要 |
Provided are animal host cells not naturally capable of forming secretory granules and that produce active, mature insulin by expression of a variant proinsulin containing a non-naturally occurring cleavage site and enzymatic cleavage of the non-naturally occurring cleavage site in the host cells. Further provided are methods of culturing such cells. |
| 申请公布号 |
DE69434519(D1) |
申请公布日期 |
2005.12.01 |
| 申请号 |
DE1994634519 |
申请日期 |
1994.03.01 |
| 申请人 |
GENENTECH, INC. |
发明人 |
GORMAN, CORNELIA M.;GROSKREUTZ, DEBYRA J. |
| 分类号 |
C12N15/09;A61K9/127;A61K48/00;C07K14/475;C07K14/48;C07K14/485;C07K14/49;C07K14/495;C07K14/50;C07K14/515;C07K14/52;C07K14/525;C07K14/53;C07K14/54;C07K14/555;C07K14/575;C07K14/58;C07K14/59;C07K14/61;C07K14/62;C07K14/64;C07K14/65;C12N5/10;C12N9/64;C12N15/12;C12N15/16;C12N15/17;C12N15/57;C12N15/62;C12N15/85;C12P21/02;C12R1/91;(IPC1-7):C12N15/57;A61K31/70 |
主分类号 |
C12N15/09 |
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