发明名称 |
Use of deltaPKC peptides for modulation of reactive oxygen species |
摘要 |
Methods for modulating the level of reactive oxygen species (ROS) in a cell or tissue by administering compounds that modulate the activity of deltaPKC are described. In one embodiment, the level of ROS is decreased by administering a peptide effective to inhibit the activity of deltaPKC. In another embodiment, the level of ROS is increased by administering a peptide having activity to agonize the activity of deltaPKC. Also described are methods to treat or inhibit development of conditions preceded by or exacerbated by an increased level of ROS, such as arteriosclerosis and inflammatory diseases.
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申请公布号 |
US2005267030(A1) |
申请公布日期 |
2005.12.01 |
申请号 |
US20050119098 |
申请日期 |
2005.04.29 |
申请人 |
TSAO PHILIP S;MOCHLY-ROSEN DARIA |
发明人 |
TSAO PHILIP S.;MOCHLY-ROSEN DARIA |
分类号 |
A61K38/00;A61K38/08;A61K38/17;A61K38/18;A61K38/45;A61K38/48;A61K38/55;C07K5/103;C07K7/06;C07K14/47;C07K14/705;C12N9/12;(IPC1-7):A61K38/18 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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