Disclosed are cochleates and cochleate compositions that associated with an replacement enzyme component and/or a plasmid component that encodes a replacement enzyme. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of replacement enzymes and/or plasmids encoding the same in a variety of dosage forms.
申请公布号
WO2005074888(A3)
申请公布日期
2005.12.01
申请号
WO2005US03778
申请日期
2005.02.03
申请人
BIODELIVERY SCIENCES INTERNATIONAL, INC.;O'DONNELL, FRANCIS, E., JR.;GOULD-FOGERITE, SUSAN;MANNINO, RAPHAEL, J.
发明人
O'DONNELL, FRANCIS, E., JR.;GOULD-FOGERITE, SUSAN;MANNINO, RAPHAEL, J.