发明名称 |
RAF MODULATORS AND METHODS OF USE |
摘要 |
The present invention relates to compounds of the Formula I, wherein G, A, X 1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
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申请公布号 |
CA2565200(A1) |
申请公布日期 |
2005.12.01 |
申请号 |
CA20052565200 |
申请日期 |
2005.03.25 |
申请人 |
EXELIXIS, INC. |
发明人 |
BLAZEY, CHARLES M.;BOWLES, OWEN JOSEPH;DUBENKO, LARISA;RICE, KENNETH D.;KENNEDY, ABIGAIL R.;DEFINA, STEVEN CHARLES;KIM, ANGIE I.;ANAND, NEEL KUMAR;MANALO, JEAN-CLAIRE L.;PETO, CSABA J.;CURTIS, JEFFRY KIMO;COSTANZO, SIMONA;TSANG, TSZE H.;BUSSENIUS, JOERG;JOSHI, ANAGHA ABHIJIT |
分类号 |
A61K31/4965;C07D401/14;C07D403/04;C07D403/06;C07D403/14;C07D405/14;C07D409/14;C07D413/06;C07D413/14 |
主分类号 |
A61K31/4965 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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