发明名称 |
PREPARACOES AQUOSAS DE AEROSSOL CONTENDO MACROMOLECULAS BIOLOGICAMENTE ACTIVAS E PROCESSO PARA A PREPARACAO DOS RESPECTIVOS AEROSSOIS |
摘要 |
Preparation of aerosols for inhalative application of biologically active macromolecules (I) (especially peptides), from an aerosol preparation which contains (I), comprises: (a) measuring a dosage amount of (I) in a measuring chamber in a nebuliser which is free of propellant gases; and (b) spraying (I) to inhalable droplets (with a particle size less than 10 mu m) within 1-2 seconds. Spraying is carried out at a pressure of 100-500 bar through a nozzle with a hydraulic diameter of 1-12 mu m. Also claimed is an aqueous aerosol composition for inhalative administration of (I), which contains 3-100 mg of (I) per ml. |
申请公布号 |
PT1003478(E) |
申请公布日期 |
2005.11.30 |
申请号 |
PT19980943814T |
申请日期 |
1998.07.31 |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
HERBERT LAMCHE;BERND ZIERENBERG;REIMHOLZ, RALPH, CHRISTIAN;MEADE, CHRISTOPHER JOHN MONTAGUE |
分类号 |
A61K9/06;A61K9/00;A61K9/12;A61K31/7088;A61K38/04;A61K38/17;A61K38/20;A61K38/21;A61K38/22;A61K38/23;A61K38/28;A61K38/29;A61K38/44;A61K38/45;A61K38/46;A61K39/00;A61L9/12;A61M15/00;(IPC1-7):A61K9/00 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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