发明名称 Hypersulfated disaccharides and methods of using the same for the treatment of inflammations
摘要 Disclosed are compounds of the formula (I), wherein; R1, R2, R3, R4, R5, and R6 are either SO3-, PO3- or H; and wherein at least three of the group consisting of R1, R2, R3, R4, R5, and R6 are each independently either SO3-, or PO3-; provided that if R3, and R4 are both SO3- then at least one of the group consisting of R1, R2, R5, and R6 are either SO3-, or PO3-; or R3, R4, R5, are SO3-, then at least one of the group consisting of R1, R2, and R6 are either SO3-, or PO3-; or R1, and R4, are both SO3- and R3 is not SO3-, then at least one of the group consisting of R2, R5, and R6 are either SO3-, or PO3. Further disclosed is the use of compounds of formula (I) in the preparation of a medicament for treating or alleviating the symptoms of inflammatory reactions in a mammalian patient with the proviso that if only R3, R4, R5are SO3- in any compound then said medicament is enriched for said compound.
申请公布号 NZ529036(A) 申请公布日期 2005.11.25
申请号 NZ20020529036 申请日期 2002.04.16
申请人 IVAX RESEARCH, INC 发明人 AHMED, TAHIR;SMITH, GREGORY A
分类号 A61K9/08;A61K9/12;A61K9/20;A61K9/48;A61K9/72;A61K31/7024;A61P1/04;A61P11/00;A61P11/02;A61P11/06;A61P11/08;A61P13/12;A61P17/00;A61P19/02;A61P27/14;A61P29/00;A61P37/08;C07B61/00;C07H11/00;C07H11/04;C07H17/04;C08B37/00;(IPC1-7):C07H17/04;A61K31/701 主分类号 A61K9/08
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