发明名称 |
MOLECULES INVOLVED IN PROTEIN FOLDING |
摘要 |
The present invention provides a method of identifying a molecule which functions as a catalyst of protein folding in a cell, which comprises: (a) transforming a library of cells with a gene encoding a reporter protein; (b) selecting those cells which contain said gene but wherein said reporter protein has reduced activity; (c) transforming the selected cells with a genomic library and then selecting those cells wherein the activity of the reporter protein has. been restored; and (d) for those cells selected at (c) above, analysing the nucleic acid sequence that was introduced during the second transformation event as part of step (c), molecules identified thereby and methods of protein production which employ said molecules. |
申请公布号 |
WO2005111060(A2) |
申请公布日期 |
2005.11.24 |
申请号 |
WO2005GB01907 |
申请日期 |
2005.05.17 |
申请人 |
EL-GEWELY, RAAFAT;GARDNER, REBECCA |
发明人 |
EL-GEWELY, RAAFAT |
分类号 |
C07K1/00;C07K1/113;C12N15/10;C12P21/02 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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