| 发明名称 |
Neutral-cationic lipid for nucleic acid and drug delivery |
| 摘要 |
A lipid represented by the formula: wherein each of R<SUP>1 </SUP>and R<SUP>2 </SUP>is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0-20; L is selected from the group consisting of (i) -X-(C-O)-Y-, (ii) -X-(C-O)-, and (iii) -X-CH<SUB>2</SUB>-, wherein X and Y are independently selected from oxygen, NH and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.
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| 申请公布号 |
US2005260261(A1) |
申请公布日期 |
2005.11.24 |
| 申请号 |
US20050133879 |
申请日期 |
2005.05.19 |
| 申请人 |
HUANG SHI K;ZALIPSKY SAMUEL;ZHANG WEI-MING;JIN BEI;QUINN YOLANDA P |
发明人 |
HUANG SHI K.;ZALIPSKY SAMUEL;ZHANG WEI-MING;JIN BEI;QUINN YOLANDA P. |
| 分类号 |
C07D233/02;A61K9/127;A61K31/7105;A61K31/711;A61K47/22;A61K47/44;A61K48/00;A61P35/00;A61P43/00;C07D233/54;(IPC1-7):C07D233/54 |
主分类号 |
C07D233/02 |
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