发明名称 |
TETRAHYDROPYRANYL CYCLOPENTYL 1-SUBSTITUTED AND 1,1-DISUBSTITUTED TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
摘要 |
Compounds of Formula I: I (wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved. |
申请公布号 |
WO2005110409(A2) |
申请公布日期 |
2005.11.24 |
申请号 |
WO2005US13856 |
申请日期 |
2005.04.22 |
申请人 |
MERCK & CO., INC.;YANG, LIHU;MILLS, SANDER, G.;MORRIELLO, GREGORI, J.;GUIADEEN, DEODIALSINGH;SHANKARAN, KOTHANDARAMAN |
发明人 |
YANG, LIHU;MILLS, SANDER, G.;MORRIELLO, GREGORI, J.;GUIADEEN, DEODIALSINGH;SHANKARAN, KOTHANDARAMAN |
分类号 |
A61K31/353;A61K31/47;C07D405/12;C07D471/04 |
主分类号 |
A61K31/353 |
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