Azabicyclo-octane inhibitors of IAP

摘要

The invention provides novel inhibitors of IAP that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: X₁ and X₂ are independently O or S; L is a bond or -C(X₃)-, -C(X₃)NR₁₂, -C(X₃)O- wherein X₃ is O or S and R₁₂ is H or R₁; R₁ is alkyl, a carbocycle, carbocycle-substituted alkyl, a heterocycle or heterocycle-substituted alkyl, wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, haloalkyl, alkoxy, alkylsulfonyl, amino, nitro, aryl and heteroaryl; R₂ is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, a heterocycle or heterocyclylalkyl; R₃ is H or alkyl; R₄ and R_4' are independently H, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, or heteroaralkyl wherein each is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, alkoxy, amino and nitro; R₅, and R₅ are each independently H or alkyl; R₆ is H or alkyl; and salts and solvates thereof.