NUCLEIC ACID-PEPTIDE DISPLAY LIBRARIES CONTAINING PEPTIDES WITH UNNATURAL AMINO ACID RESIDUES, AND METHODS OF MAKING SAME

摘要

Libraries of nucleic acid-peptide fusion molecules are provided, wherein the peptide component of the fusion molecules contains one or more unnatural amino acid residues. Methods of making such libraries using one or more peptide modifying agents also are provided, as are methods of screening such libraries to identify peptides having desirable characteristics. Accordingly, isolated nucleic acid-peptide molecules also are provided, wherein the peptide component has a desirable characteristic, and is composed partially or entirely of unnatural amino acid residues.