| 发明名称 |
Selvsamlende, rekombinante HPV16-papillomavirus-capsidproteiner |
| 摘要 |
<p>Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.</p> |
| 申请公布号 |
DK0662132(T3) |
申请公布日期 |
2005.11.21 |
| 申请号 |
DK19930921353T |
申请日期 |
1993.09.03 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SCHILLER, JOHN, T.;LOWY, DOUGLAS, R.;KIRNBAUER, REINHARD |
| 分类号 |
G01N33/53;A61K39/00;A61K39/12;A61K39/23;A61P17/12;A61P31/12;A61P31/20;A61P35/00;C07K14/025;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N7/04;C12N15/09;C12N15/37;C12P21/02;C12Q1/70;C12R1/91;G01N33/566;G01N33/569;(IPC1-7):C07K14/025;C12N15/866 |
主分类号 |
G01N33/53 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
