METHOD FOR PREPARING QUINOLINE CARBOXALDEHYDE DERIVATIVE AND INTERMEDIATE COMPOUNDS

摘要

FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: derivative of quinoline carboxaldehyde i. e. 2-cyclopropyl-4-(4'-fluorophenyl)quinoline 3-carboxaldehyde is prepared by interaction of 3-cyclopropyl-3-oxopropane nitrile with 2-amino-4'-fluorobenzophenone to yield 2-cyclopropyl-4-(4'-fluorophenyl)quinoline 3-carbonitrile followed by its reduction. ^ EFFECT: enhanced yield of end product, simplified process. ^ 8 cl, 11 ex