发明名称 Method of resolving amlodipine racemate.
摘要 The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipitation with tartaric acid in the presence of a non-aqueous solvent, such as N,N'-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 or greater than 0.75:1.0.
申请公布号 ZA200403052(B) 申请公布日期 2005.11.18
申请号 ZA20040003052 申请日期 2004.04.21
申请人 SEPRACOR INC. 发明人 SENANAYAKE, CHRIS, H.;WILKINSON, HAROLD, S.;ZLOTA, ANDREI, A.;TANOURY, GERALD, J.;BAKALE, ROGER, P.;KOSTAS SARANTEAS
分类号 A61K31/4422;A61P9/10;A61P9/12;C07D211/90 主分类号 A61K31/4422
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