发明名称 |
On-demand cleavable linkers for radioconjugates for cancer imaging and therapy |
摘要 |
The present invention provides compositions comprising a biological agent, a targeting moiety, and a peptide linker attaching the biological agent to the targeting moiety, wherein the peptide linker is selectively cleaved by a protease. Efficient methods are provided for administering the compositions of the present invention for treating cancer or imaging a tumor, organ, or tissue in a subject. Kits are also provided for administering the compositions of the present invention for radiotherapy or radioimaging.
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申请公布号 |
US2005255042(A1) |
申请公布日期 |
2005.11.17 |
申请号 |
US20040997759 |
申请日期 |
2004.11.23 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER, UNIVERSITY OF CALIFORNIA |
发明人 |
LAM KIT S.;KUMARESAN PAPPANAICKEN;DENARDO SALLY;DENARDO GERALD |
分类号 |
A61K;A61K51/00;(IPC1-7):A61K51/00 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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