| 发明名称 |
REVERSIBLE ATTACHMENT OF A MEMBRANE ACTIVE POLYMER TO A POLYNUCLEOTIDE |
| 摘要 |
Described is a process for delivering a biologically active compound to a cell by reversibly linking the compound to a membrane active polymer. In particular, polymer-polynucleotide conjugates are described. Methods for reversibly modifying the polymers to decrease cellular toxicity and improve efficacy are provided. |
| 申请公布号 |
EP1594977(A2) |
申请公布日期 |
2005.11.16 |
| 申请号 |
EP20040712281 |
申请日期 |
2004.02.18 |
| 申请人 |
MIRUS CORPORATION |
发明人 |
ROZEMA, DAVID, B.;WAKEFIELD, DARREN |
| 分类号 |
A61K9/127;A01N43/04;A61K47/48;A61K48/00;C12N15/11;C12Q;C12Q1/00;(IPC1-7):A61K9/127 |
主分类号 |
A61K9/127 |
| 代理机构 |
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