| 摘要 |
PROBLEM TO BE SOLVED: To obtain a reagent for optical resolution capable of producing an optically active 3-aminopyrrolidine derivative useful as a synthetic raw material for medicines and agrochemicals in high optical purity and yield by chemically modifying an optically active amino acid or optically active tartaric acid. SOLUTION: This compound is selected from an optically active N-acrylamino acid derivative of formula I (R<1> is a 1-10C alkyl or unsubstituted aromatic ring or a substituted aryl, etc.; R<2> is H, a 1-10C alkyl, etc.), an optically active N-sulfonylamino acid derivative of formula II [R<3> is a (substituted)1-10C alkyl or an unsubstituted aromatic ring or a substituted aryl, etc.; R<4> is a 1-10C alkyl, an aromatic group such as an unsubstituted aromatic or a substituted aryl, etc.] and an optically active tartaric anilide of formula III (R<5> is H, a 1-10C alkyl, an alkoxy, nitro or a halogen), specifically, optically active N- acetylphenylalanine, optically active N-p-toluoylphenylglycine, optically active N-p-nitrobenzoylalanine, etc. |
