| 摘要 |
A particle size-controlling substance containing a drug, polyethylene oxide having a molecular weight of 2,000,000 or more and a particle size- controlling agent (a substance having appropriate plasticizing properties and binding force) for the polyethylene oxide wherein at least the particle size-controlling agent as specified above is uniformly dispersed in the polyethylene oxide; a medicinal composition for regulating release which contains the particle size-controlling substance; and a process for producing the medicinal composition for regulating release which contains the particle size-controlling substance. By using polyethylene oxide powder/grains in which the specific particle size-controlling agent for polyethylene oxide is uniformly dispersed and which have powder characteristics appropriate for tabletting, a medicinal composition for regulating release showing favorable content uniformity can be provided.
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