摘要 |
Disclosed are A<SUB>1 </SUB>adenosine receptor agonists of the formula: wherein: R<SUP>1 </SUP>is optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; R<SUP>2 </SUP>is hydrogen, halo, trifluoromethyl, or cyano; R<SUP>3 </SUP>is hydrogen, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl, R<SUP>4 </SUP>and R<SUP>5 </SUP>are independently hydrogen or optionally substituted acyl; X is a covalent bond or lower alkylene optionally substituted by cycloalkyl; X<SUP>1 </SUP>is a covalent bond or alkylene; Y is a covalent bond or lower alkylene optionally substituted by hedroxy or cycloalkyl; and Z is -C≡C-, -R<SUP>6</SUP>C-CR<SUP>7</SUP>-, or -CHR<SUP>6</SUP>CHR<SUP>7</SUP>-, in which R<SUP>6 </SUP>and R<SUP>7 </SUP>at each occurrence are hydrogen or lower alkyl. |