发明名称 |
PROCESS FOR PREPARING RAPAMYCIN 42-ESTERS AND FK-506 32-ESTERS WITH DICARBOXYLIC ACID, PRECURSORS FOR RAPAMYCIN CONJUGATES AND ANTIBODIES |
摘要 |
Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic aci d with a lipase.
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申请公布号 |
CA2562962(A1) |
申请公布日期 |
2005.11.10 |
申请号 |
CA20052562962 |
申请日期 |
2005.04.12 |
申请人 |
WYETH |
发明人 |
RUPPEN, MARK E.;CAI, PING;GU, JIANXIN |
分类号 |
C07D498/18;A61K47/48;C12P17/10;C12P17/18 |
主分类号 |
C07D498/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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