COMPOSITIONS COMPRISING ONE OR MORE POLICOSANOLS AND/OR POLICOSANOIC ACIDS COMBINED WITH STEROL AND/OR STEROID BASED ASCORBIC ACID DERIVATIVES, AND USES THEREOF

摘要

A composition comprising one or more long chain alcohols (policosanols) and/or their respective acids (policosanoic acids) and one or more ascorbic acid derivatives, including all biologically acceptable salts or solvates or prodrugs of at least one such derivative or of the salts or of the solvates thereof represented by the following general formulae I-IV wherein, in formulae I, II and III, represent derivatives of androstene and androstane, R1, R2, R3, R4, R5, R6 may individually be chosen from hydrogen, OH, carbonyl, and an ascorbyl-based moiety; and R7 may be hydrogen or any halogen; and wherein, in formula IV, R8 is an ascorbyl-based moiety and R9 is a sterol or stanol moiety. The composition is used for the treatment and prevention of cardiovascular disease and for lowering serum cholesterol.