METALLIZATION OF NUCLEIC ACIDS BY METAL SOLS, AND USES THEREOF

摘要

The present invention relates to a method for metallizing a nucleic acid molecule by providing a metal sol, mordanting metal particles from the metal sol on the nucleic acid molecule, and contacting the mordanted nucleic acid molecule with a metal deposition solution to deposit metal on the nucleic acid molecule. A method for detecting a target nucleic acid molecule in a sample employing metallized nucleic acid molecules is also disclosed.