发明名称 |
DERIVATIVES OF 14.15-DIHYDRO 20.21-DINOREBURNAMENIN-14-OL, AND APPLICATIONS THEREOF |
摘要 |
<p>The invention relates to novel derivatives of 14,15-dihydro 20,21 dinoreburnamenin-14-ol, having formula (I), in which R represents a radical -AR', wherein A represents a heteroatom and R' represents a group selected from the group comprising alkyl radicals at C1-C6, alkenyls at C1-C6, alkynyls at C1-C6, aralkyls; esters having formula -R1-CO-O-R2; amides having formula -R3-CO-NZY, wherein Y and Z together can form a cycloalkyl radical or a heterocyclic radical, optionally substituted by one or more alkyl radicals; a radical selected from the group comprising alkyl radicals, alkenyls or alkynyls, substituted by at least one amine having formula -NZY; or one of the pharmaceutically-acceptable salts thereof, including the isomers, enantiomers and diastereoisomers thereof and mixtures of same. The invention also relates to the use of said novel derivatives for the preparation of a pharmaceutical composition which is intended, in particular, for the treatment and/or prevention of depression, sleep/wake cycle disorders and symptomatic frontal disorders in cognitive components among humans.</p> |
申请公布号 |
WO2005103047(A1) |
申请公布日期 |
2005.11.03 |
申请号 |
WO2005FR00902 |
申请日期 |
2005.04.14 |
申请人 |
BIOCORTECH;CIAPETTI, PAOLA;DEYON, LAURENCE;WERMUTH, CAMILLE-GEORGES;PUJOL, JEAN-FRANCOIS;WEISSMANN, DINAH |
发明人 |
CIAPETTI, PAOLA;DEYON, LAURENCE;WERMUTH, CAMILLE-GEORGES;PUJOL, JEAN-FRANCOIS;WEISSMANN, DINAH |
分类号 |
C07D461/00;(IPC1-7):C07D461/00;A61P25/24;A61K31/437;A61P25/18 |
主分类号 |
C07D461/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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