Pharmaceutical composition comprising aspartyl protease inhibitor, which is sulfonamide containing tetrahydrofuran ring and use thereof

摘要

Described is a pharmaceutical composition comprising sulfonamide of general formula (I), wherein R1 is oxyorganic residue, D a D' is optionally always substituted aryl, optionally substituted carbocycle or optionally substituted heterocycle, optionally substituted C1-C5-alkyl or optionally substituted C2-C4-alkenyl, E is optionally substituted C3-C7-carbocycle, optionally substituted C6-C10-aryl, optionally phenyl substituted with fused heterocycle, optionally substituted heterocycle, optionally substituted hydroxy group, optionally substituted amino group, optionally substituted C1-C6-alkyl, optionally substituted C2-C6-alkenyl, which are aspartyl protease inhibitors. This pharmaceutical composition is suitable for inhibiting HIV-1 or HIV-2 protease activity and consequently may be used as anti-viral agents against the HIV-1 and HIV-2 viruses.