发明名称 |
Thienopyrimidine compounds and use thereof |
摘要 |
The present invention provides a compound represented by the formula: wherein R1 is a C1-4 alkyl; R2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a hydroxy group, (3′) a C1-4 alkyl and (4′) a C1-4 alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a C1-4 alkoxy-C1-4 alkyl, (3′) a mono-C1-4 alkyl-carbamoyl-C1-4 alkyl, (4′) a C1-4 alkoxy and (5′) a mono-C1-4 alkylcarbamoyl-C1-4 alkoxy, or the like; R3 is a C1-4 alkyl; R4 is a C1-4 alkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity. |
申请公布号 |
EP1591446(A1) |
申请公布日期 |
2005.11.02 |
申请号 |
EP20040705950 |
申请日期 |
2004.01.28 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
CHO, NOBUO;IMADA, TAKASHI;HITAKA, TAKENORI;MIWA, KAZUHIRO;KUSAKA, MASAMI;SUZUKI, NOBUHIRO |
分类号 |
A61K31/519;A61P1/04;A61P5/04;A61P5/24;A61P13/08;A61P15/00;A61P15/08;A61P15/18;A61P17/10;A61P17/14;A61P25/28;A61P35/00;A61P43/00;C07D495/04 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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