发明名称 |
Echinocandin pharmaceutical formulations containing micelle-forming surfactants |
摘要 |
Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.
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申请公布号 |
US6960564(B2) |
申请公布日期 |
2005.11.01 |
申请号 |
US20010942431 |
申请日期 |
2001.08.29 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
MILTON NATHANIEL;MODER KENNETH PHILIP;SABATOWSKI JAMES LAWRENCE;SWEETANA STEPHANIE ANN |
分类号 |
A61K9/08;A61K9/107;A61K9/19;A61K31/407;A61K38/00;A61K38/12;A61P31/10;(IPC1-7):A61K38/12 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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