摘要 |
FIGURE ITHE INVENTION CONCERNS A PHARMACEUTICAL COMPOSITIONS CONTAINING AS ACTIVE PRINCIPLES: A CONSTITUENT (A) SELECTED BETWEEN 1-(2-NAPHT-2-YLETHYL)-4-(3-TRIFLUOROMETHYLPHENYL)-1, 2, 3, 6-TETRAHYDROPYRIDIN AND A COMPOUND (I) IN WHICH: Y REPRESENTS -CH- OR -N-; R1 REPRESENTS HYDROGEN, A HALOGEN, A HYDROXYL, A CF3, A (C3-C4) ALKYL OR (C1-C4) ALKOXYL GROUP; R2 REPRESENTS HYDROGEN, A HALOGEN, A HYDROXYL, A CF3, (C3-C4) ALKYL OR (C1-C4) ALKOXYL GROUP; R3 AND R4 REPRESENT EACH HYDROGEN OR A (C1-C4) ALKYL; X REPRESENTS (A) A (C3-C6) ALKYL; A (C3-C6) ALKOXYL; A (C3-C7) CARBOXYALKYL; A (C1-C4) ALKOXYCARBONYL (C3-C6-) ALKYL; A (C3-C7) CARBOXYALKOXYL; OR A (C1-C4) ALKOXYCARBONYL (C3-C6) ALKOXYL; (B) A RADICAL SELECTED AMONG A (C3-C7) CYCLOALKYL, (C3-C7) CYCLOALKYLOXY, (C3-C7) CYCLOALKYLMETHYL, (C3-C7) CYCLOALKYLAMINO AND CYCLOHEXENYL, SAID RADICAL CAPABLE OF BEING SUBSTITUTED BY A HALOGEN, HYDROXY, (C1-C4) ALKOXY, CARBOXY, (C1-C4) ALKOXYCARBONYL, AMINO, MONO- OR DI- (C1-C4) ALKYAMINO OR (C)A GROUP SELECTED AMONG PHENYL, PHENOXY, PHENYLAMINO, N-(C1-C3) ALKYL-PHENYL-AMINO, PHENYLMETHYL, PHENYLETHYL, PHENYLCARBONYL, PHENYLTHIO, PHENYLSULPHONYL, PHENYLSULPHINYL AND STYRYL, SAID GROUP CAPABLE OF BEING MONO- OR POLYSUBSTITUTED ON THE PHENYL GROUP BY A HALOGEN, CF3, (C1-C4) ALKYL, (C1-C4) ALKOXY, CYANO, AMINO, MONO OR DI-(C1-C4) ALKYLAMINO, (C1-C4) ACYLAMINO, CARBOXY, (C1-C4) ALKOXYCARBONYL, AMINOCARBONYL, MONO- OR DI-(C-C4) ALKYLAMINOCARBONYL, AMINO (C1-C4) ALKYL, HYDROXY (C1-C4) ALKYL, OR HALOGENO (C1-C4) ALKYL; OPTIONALLY IN THE FORM OF ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS; AND AN CONCTITUENT (B)ACTIVE IN THE SYMPTOMATIC TREATMENT OF DAT, OPTIONALLY IN THE FORM OF ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS, PROVIDED THAT WHEN CONSTITUENT (A) IS OTHER THAN 1-(2NAPTH-2-YLETHYL)-4-(3-TRIFLUOROMETHYLPHENYL)-1, 2, 3, 6-TETRAHYDROPYRIDIN OR ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS, THE CONSTITUENT (B) IS AN ACETYLCHOLINESTERASE INHIBITING AGENT.
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