发明名称 |
Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide |
摘要 |
The present invention relates to a novel process, suitable for industrial exploitation for the production of N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide, also known as N-lidocaine, obtained from the reaction of piperazine with N-haloacetyl-2,6-xylidine. The process comprises the consecutive steps a) through f) a) reacting piperazine with N-haloacetyl-2,6-xylidine in a molar ratio between about 1/1 and about 6/1 in an aqueous solvent in which has been dissolved an equimolar amount of HCl; b) separating the solid formed in step a) from the reaction mixture; c) neutralizing the filtrate; d) extracting the filtrate with a solvent which is not or only to a small extent miscible with the aqueous solvent mentioned in step a); e) crystallizing the N-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide from the solvent mentioned in step d) and f) separating the solid obtained in step e) from the solvent mentioned in step d).
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申请公布号 |
US2005240018(A1) |
申请公布日期 |
2005.10.27 |
申请号 |
US20030518887 |
申请日期 |
2003.06.19 |
申请人 |
GUILLAUME MICHEL JOSEPH MAURIC;CUYPERS JOSEF LUDO JAN;VERVEST IVAN JOSEPH MARIA;LEURS STEFAN MARCEL HERMAN;DE SMAELE DIRK |
发明人 |
GUILLAUME MICHEL JOSEPH MAURICE A.;CUYPERS JOSEF LUDO JAN;VERVEST IVAN JOSEPH MARIA;LEURS STEFAN MARCEL HERMAN;DE SMAELE DIRK |
分类号 |
C07D295/14;C07D295/15;(IPC1-7):C07D241/04 |
主分类号 |
C07D295/14 |
代理机构 |
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代理人 |
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主权项 |
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