THE IL-1 GENE CLUSTER AND ASSOCIATED INFLAMMATORY POLYMORPHISMS AND HAPLOTYPES
摘要
The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster-including the structure and organization of novel IL-1 like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus - which contains the previously-identified IL-1alpha, IL-1beta and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-1 haplotype associated inflammatory phenotypes.
申请公布号
WO03064600(A3)
申请公布日期
2005.10.27
申请号
WO2003US02232
申请日期
2003.01.27
申请人
INTERLEUKIN GENETICS, INC.
发明人
NICKLIN, MARTIN;DUFF, GORDON;KORNMAN, KENNETH;KOLPIN, MARYAM, RAFIE;HSIEH, CHUNG-MING;GOVINDARAJU, RAJU;AZIZ, NAZNEEN;CANNING, CHRIS