Methods and compositions for delivering siRNA into mammalian cells

摘要

Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR₁KRKVR₂ and an appropriate siRNA, wherein R₁ represents any amino acid residue and more preferably K or S, R₂ is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C₁-C₆ alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.