发明名称 |
Transgenic mice overexpressing aspartyl protease 2 (ASP2) |
摘要 |
The present invention provides a recombinant DNA construct comprising a coding sequence encoding human ASP2 and a brain-specific calcium calmodulin kinase promoter sequence which is operably linked to the coding sequence. The present invention further provides a transgenic non-human animal whose genome incorporates a polynucleotide comprising a coding sequence which encodes the human ASP2 protein wherein the coding sequence is operably linked to a brain-specific calcium calmodulin kinase II promoter.
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申请公布号 |
US6958433(B2) |
申请公布日期 |
2005.10.25 |
申请号 |
US20020223837 |
申请日期 |
2002.08.20 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
GEPPERT MARTIN;HARPER ALEXANDER JAMES;HARRISON STEVE MARK;PROSSER HAYDN |
分类号 |
A01K67/027;C07K14/47;C12N9/64;C12N15/57;C12N15/85;(IPC1-7):A01K67/027;C07H21/04;C12N5/10;C12N5/18 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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