| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for simply preparing a ketone compound in high yield at high purity. SOLUTION: In preparing a ketone compound such as 2-(10,11-dihydro-10-oxydibenzo[b,f]thiepin-2-yl)propionic acid by the Friedel-Crafts reaction type intramolecular cyclization of a dicarboxylic acid compound such as 5-(1-carboxyethyl)-2-phenylthiophenylacetic acid, a polyphosphoric acid which is prepared by mixing phosphoric acid with diphosphorus pentoxide and has a phosphoric acid concentration of 110-130 mass% and a viscosity at 25°C of 700-1,000 mPa s is used as a condensing agent. COPYRIGHT: (C)2006,JPO&NCIPI
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