| 发明名称 |
Inhibition of protein kinases with piridinylimidazoles |
| 摘要 |
a method of inhibiting a protein kinase that has a threonine or less bulky residue at the position equivalent to Thr 106 in SAPK2a/p38, and not mammalian SAPK2a/p38 or SAPK2b/p38beta2, is provided, wherein the protein kinase is exposed to a pyridinyl imidazole inhibitor. The protein kinase may be a TGFbeta type-I or type-II receptor.
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| 申请公布号 |
US2005234094(A1) |
申请公布日期 |
2005.10.20 |
| 申请号 |
US20050030487 |
申请日期 |
2005.01.06 |
| 申请人 |
SMITHKLINE BEECHAM P.L.C. |
发明人 |
COHEN PHILIP;GOEDERT MICHEL;EYERS PATRICK A. |
| 分类号 |
A01K67/027;A61K31/4427;A61K31/4439;A61K31/4545;A61P35/00;A61P43/00;C07D401/04;C07D401/14;G01N33/15;G01N33/50;(IPC1-7):A61K31/474;C12Q1/48 |
主分类号 |
A01K67/027 |
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