Method of inhibiting vascular permeability

摘要

The present invention provides a method of regulating vascular permeability. A peptide inhibitor of p21-activated kinase has been found to inhibit the increase in vascular permeability induced by several factors. The present invention further provides methods of identifying regulators of vascular permeability. This peptide or other p21-activated kinase inhibitors should therefore be useful to treat disorders where vascular leak is a contributing factor.