DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH POTASSIUM CHANNEL, SUBFAMILY K, MEMBER 1 (KCNK1)

摘要

The invention provides a human KCNK1 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, neurological diseases (e.g. Alzheimer), hematological diseases, cancer (e.g. esophagus, colon, ileum, lung, breast tumor), inflammation and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, neurological diseases, hematological diseases, cancer, inflammation and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of KCNK1 as well as pharmaceutical compositions comprising such compounds.