发明名称 |
ANTIBODIES DIRECTED TO MONOCYTE CHEMO-ATTRACTANT PROTEIN-1 (MCP-1) AND USES THEREOF |
摘要 |
Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fully human monoclonal antibodies directed to the antigen MCP-1. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided. |
申请公布号 |
EP1542724(A4) |
申请公布日期 |
2005.10.19 |
申请号 |
EP20030788686 |
申请日期 |
2003.08.19 |
申请人 |
ABGENIX, INC. |
发明人 |
GUDAS, JEAN, M.;HAAK-FRENDSCHO, MARY;FOORD, ORIT;LIANG, MEINA, L.;AHLUWALIA, KIRAN;BHAKTA, SUNIL |
分类号 |
G01N33/53;A61K39/395;A61P9/10;A61P13/12;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P35/00;A61P35/04;A61P37/00;A61P43/00;C07K16/00;C07K16/24;C07K17/00;C12N15/09;C12P21/08 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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