发明名称 |
GLYCEROL DERIVATIVE, DEVICE AND PHARMACEUTICAL COMPOSITION |
摘要 |
The object of the invention is to provide a lipid device functionally equivalent to the so-called cationic liposome and of lesser toxicity and a lipid or the like as a component of the device. The compound of the invention includes but is not limited to 3-O- (4-dimethylaminobutanoyl)-1,2-O-dioleylglycerol, 3-O-(2-dimethyl- aminoethyl)carbamoyl-1,2-O-dioleylglycerol, 3-O-(2-diethylaminoethyl) carbamoyl-1,2-O-dioleylglycerol and 2-O-(2-diethylaminoethyl) carbamoyl-1,3-O-dioleoylglycerol. The device of the invention comprises such a lipid and a phospholipid. By administering a double-stranded RNA, for instance, together with the device of the invention, the double-stranded RNA can be safely delivered to the site of action.
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申请公布号 |
CA2156288(C) |
申请公布日期 |
2005.10.18 |
申请号 |
CA19942156288 |
申请日期 |
1994.02.17 |
申请人 |
NIPPON SHINYAKU CO., LTD. |
发明人 |
YANO, JUNICHI;OHGI, TADAAKI |
分类号 |
A61K31/70;A61K9/127;A61K9/52;A61K9/66;A61K47/10;A61K47/24;A61K47/44;C07C229/06;C07C229/12;C07C237/08;C07C271/16;C07C271/20;C07C279/04;C07C279/20;C07C307/02;C07C333/04;C07D207/08;C07D211/08;C07D241/04;C07D265/30;C07D295/13;C07F9/40;(IPC1-7):C07C271/20;C07C279/14;C07D295/15;C07C229/16;G01N33/48;G01N33/566;C07F9/572;A61K31/685;C07K14/705 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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