ANTI-SENSE OLIGONUCLEOTIDES DIRECTED TOWARDS THE HIV psi DOMAIN

摘要

Anti-sense oligonucleotides directed at the psi domain of the HIV genome, in particular, the SL3 loop/stem region of the HIV psi domain, are shown herein to disrupt the interaction of the psi domain with Gag NC, thereby inhibiting genome encapsidation and reducing the production of infectious HIV particles. These anti-sense oligonucleotides are useful as anti-retroviral therapeutics.