| 摘要 |
A pharmaceutical composition comprising microtablets, wherein said microtablets comprise from about 0.1 weight percent to about 99.9 weight percent of venlafaxine, about 0.1 weight percent to about 20 weight percent of a lubricant, and optionally one or more excipients, wherein said weight percents are based on the total weight of the microtablet, and said microtablets have a tablet size of about 1 mm to about 4 mm, and a tablet weight of 1 to 50 mg. The microtablets of the invention prevent or minimize leaching of the highly water-soluble venlafaxine during an aqueous coating process, and provide a more uniform release rate, as compared to venlafaxine compositions in the form of spheroids or pellets.
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