发明名称 |
Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
摘要 |
A process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine hydrochloride (Donepezil HCl) is disclosed. 5,6-Dimethoxy-2-(pyridin-4-yl) methylene inda-1-one is hydrogenated with a noble metal catalyst or a non-oxide derivative of a noble metal catalyst in a solvent at 20-100° C. and 10-90 psi gauge pressure. The resulting 4-[(5,6-dimethoxy-1-indanon)-2-yl] methyl piperidine is alkylated with an alkylating agent in an organic solvent at 20-80° C.
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申请公布号 |
US6953856(B2) |
申请公布日期 |
2005.10.11 |
申请号 |
US20030714724 |
申请日期 |
2003.11.17 |
申请人 |
USV, LIMITED |
发明人 |
RADHAKRISHNAN TARUR VENKATASUBRAMANIAN;GOVIND SATHE DHANAJAY;VENKATRAMAN NAIDU AVINASH |
分类号 |
C07D211/22;C07D211/32;(IPC1-7):C07D211/02;C07D211/06 |
主分类号 |
C07D211/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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