СПОСОБ ПОЛУЧЕНИЯ ЛЕКАРСТВЕННЫХ ДЕЙСТВУЮЩИХ ВЕЩЕСТВ В ВИДЕ КРИСТАЛЛОВ, ПОЛУЧАЕМЫЕ ЭТИМ СПОСОБОМ КРМСТАЛЛЫ И ИХ ПРИМЕНЕНИЕ В ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТАХ

摘要

The process for making crystals of a medicinally effective ingredient having a predetermined average particle size in a predetermined size range and a maximum particle size that does not exceed a predetermined maximum value, includes subjecting a supersaturated solution containing the medicinally effective ingredient to a wet milling by a wet milling apparatus while crystallizing, in order to obtain a primary particle suspension. Crystals obtained according to this process and pharmaceutical preparations containing them are also described.