| 摘要 |
FIELD: medicine, therapy, rheumatology. ^ SUBSTANCE: one should detect mineral density of bony tissue in lumbar vertebral department, in column femoris; from patient's life anamnesis one should detect risk factors for osseous fractures: duration of menopause, duration and index of disease severity degree, systemic manifestations of rheumatoid arthritis (RA), solitude, dosage and duration for the intake of glucocortico-steroid (GCS) preparations to establish their gradations and digital values: no risk factor - the sign has got digital value "0", if risk factor is available - "1". Then it is necessary to detect prognostic coefficients F1 and F2 by the following formulas: F1 = -38.72 - 7.27*X1 + 9.77*X2 + 6.30*X3 +4.25*X4 + 7.41*X5 + 9.66*X6 + 32.97*X7 + 3.62*X8 + 8.96*X9 + 38.04*X10 - 0.55*X11 - 0.50*X12; F2 = -5.41 - 4.32*X1 + 3.22*X2 + 2.91*X3 + 3.28*X4 + 3.24*X5 +3.93*X6 + 7.43*X7 +1.35*X8 + 1.08*X9 + 9.07*x10 - 0.11*X11 - 0.19*X12, where X1-12 - gradations and digital values of risk factors (X1 - age is above 45, X2 - postmenopause is above 5 years, X3 - RA duration is above 10 years, X4 - severity degree index is above 5 points, X5 - RA systemic manifestations, X6 - solitude, X7 - intake of GCS preparations is above 2 years, X8 - cumulative dosage of GCS is above 5000 mg, X9 - mineral density of bony tissue in lumbar vertebral department by T-criterion is below -2.5, X10 - mineral density of bony tissue in collum femoris by T-criterion is below -2.5, X11 - mineral density of bony tissue in collum femoris is below 0.700 g/sq. cm, X12 - mineral density of bony tissue in lumbar vertebral department is below 0.900 g/sq. cm). At F1>=F2 one should predict high risk for fracture possibility, and at F1<F2 - low risk for fracture chance. The innovation enables to take into consideration the sum of common and specific risk factors. ^ EFFECT: higher accuracy of prediction. ^ 4 ex, 1 tbl |
