发明名称 |
Process for preparing a dipeptidyl peptidase IV inhibitor and intermediates employed therein |
摘要 |
A process is provided for preparing a dipeptidyl peptidase IV inhibitor of the structure wherein is treated with TFAA in isopropyl acetate to protect the tertiary hydroxyl group as a trifluoroacetate group to form 4 (which is a novel intermediate) which is converted to acid chloride compound 5 (which is a novel compound) using Vilsmeier reagent or other chloro reagent and coupled with compound 6 in a heterogeneous mixture of ethyl acetate and aqueous bicarbonate to give compound 7 The N,O-bis(trifluoroacetyl) groups of compound 7 are deprotected to give free base compound 10.
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申请公布号 |
US2005222242(A1) |
申请公布日期 |
2005.10.06 |
申请号 |
US20050091183 |
申请日期 |
2005.03.28 |
申请人 |
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发明人 |
SHARMA PADAM N.;GUBLO EDWARD J.;GALVIN GABRIEL M.;BOETTGER SUSAN D.;RACHA SAIBABA |
分类号 |
A61K31/198;A61K31/403;C07C233/47;C07C233/84;C07D209/02;(IPC1-7):A61K31/403 |
主分类号 |
A61K31/198 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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