REDUCING THE RISK OF HUMAN AND ANTI-HUMAN ANTIBODIES THROUGHV GENE MANIPULATION

摘要

The present embodiments relate to methods of identifying and creating human, or humanized antibodies that possess a reduced risk of inducing a Human Anti - Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for screening for anti-HAHA compounds are also included.< /SDOAB>